Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone (INN), and as 3β-hydoxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone. It has been reported to act as a subunit-selective negative allosteric modulator of the GABAA receptor, and antagonizes in animals and humans some but not all of the GABAA receptor-mediated effects of allopregnanolone, such as anesthesia, sedation, and reduced saccadic eye movements, but not learning impairment. Isopregnanolone has no hormonal effects and appears to have no effect on the GABAA receptor by itself; it selectively antagonizes allopregnanolone and does not affect the effects of other types of GABAA receptor positive allosteric modulators such as benzodiazepines or barbiturates.

CAS：516-55-2
中文别名：
英文别名：ALLOPREGNAN-3B-OL-20-ONE;3beta-hydroxy-5alpha-pregnan-20-one;3-Hydroxypregnan-20-one;Alloepipregnanolone;Tetrahydroprogesterone;5A-PREGNAN-3B-OL-20-ONE;ALLOPREGNANOLONE;ISOPREGNANOLONE;Pregnan-20-one,3-hydroxy-, (3b,5a)-;Pregnan-20-one, 3-hydroxy-, (3β,5α)-;epi-allopregnanolone;
分子式：C21H34O2
分子量：318.493
精确质量：318.256
Psa：37.3
Logp：4.5952

UNII：3P8Z6V53MU

密度：1.053g/cm3
沸点：431.2ºC at 760mmHg
闪点：183.9ºC
折射率：1.524