5α-Dihydroprogesterone (5α-DHP), also known as 5α-pregnan-3,20-dione, is an endogenous progestogen and neurosteroid that is synthesized from progesterone. It is also an intermediate in the synthesis of allopregnanolone and isopregnanolone from progesterone. 5α-DHP is an agonist of the progesterone receptor and a positive allosteric modulator of the GABAA receptor (albeit with an affinity for this receptor that is regarded as relatively low (in comparison to 3α-hydroxylated progesterone metabolites such as allopregnanolone and pregnanolone)). It has also been found to act as a negative allosteric modulator of the GABAA-rho receptor. In addition, it is a weak agonist of the pregnane X receptor (PXR) (EC50 >10,000 µM)), with approximately six-fold lower potency relative to its 5β-isomer, 5β-dihydroprogesterone.

CAS：566-65-4
中文别名：5Α-孕甾-3,20-二酮;二氢黄体酮;5-alpha-孕甾-3,20-二酮;
英文别名：5alpha-pregnane-3,20-dione;Pregnane-3,20-dione;3,20-Dioxo-5alpha-pregnane;5alpha-Pregnan-3,20-dione;5alpha-Dihydroprogesterone;(5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one;5a-Pregnane-3,20-dione;Pregnane-3,20-dione, (5α)-;(5Alpha)-Pregnane-3,20-dione;Allopregnan-3,20-dione;3,20-Allopregnanedione;
分子式：C21H32O2
分子量：316.478
精确质量：316.24
Psa：34.14
Logp：4.8034

EINECS号：209-297-3

外观与性状：白色固体
密度：1.048 g/cm3
沸点：429.2ºC
闪点：160.3ºC
折射率：1.515
稳定性：Stable at normal temperatures and pressures.
储存条件：Keep tightly closed.

RTECS号：TU4157150