Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine. Leu-enkephalin has agonistic actions at both the μ- and δ-opioid receptors, with significantly greater preference for the latter. It has little to no effect on the κ-opioid receptor.

CAS：58822-25-6
中文别名：N-[N-[N-(N-L-酪氨酰甘氨酰)甘氨酰]-L-苯丙氨酰]-L-亮氨酸;
英文别名：ENKEPHALIN L;Leu-Enkelphalin;LEUCINE-ENKEPHALIN;L-TYR-GLY-GLY-PHE-LEU;L-leucine enkephalin;LEU-ENKEPHALIN;enkephalin,leucine;TYR-GLY-GLY-PHE-LEU;H-TyrGlyGlyPheLeu-OH;YGGFL;SGS 518 oxalate;H2N-Tyr-Gly-Gly-Phe-Leu-COOH;
分子式：C28H37N5O7
分子量：555.623
精确质量：555.269
Psa：199.95
Logp：2.1013

UNII：RI01R707R6

外观与性状：白色冻干的粉末
密度：1.274 g/cm3
沸点：998.8ºC at 760 mmHg
闪点：557.8ºC
折射率：1.586
储存条件：-20ºC

安全说明：S22-S24/25
WGK Germany：3