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化合物简介
2-Thiopheneethanol is a thiophene derivative used in the preparation of oligothiophene isothiocyanates as fluorescent markers for biopolymers. 2-Thiopheneethanol is also used in the preparation of other biologically active compounds such as the analgesic Sulfentanyl and the antithrombotic Clopidogrel Hydrogen Sulfate.
基本信息
CAS:5402-55-1
中文别名:2-(2-噻吩基)乙醇;2-(2-羟乙基)噻吩;2-噻吩乙醇;噻吩-2-乙醇;2-(2-噻吩)乙醇,2-(2-噻吩基)乙醇;
英文别名:2-Thiophenethanol;THIOPHENE-2-ETHYANOL;2-THIOPHENETHANOL;THIOPHENE-2-ETHANOL;2-(2-Thienyl)ethanol;2-THIENYLETHANOL;Thiopheneethanol;2-Thienylethanol;
分子式:C6H8OS
分子量:128.192
精确质量:128.03
Psa:48.47
Logp:1.2829
中文别名:2-(2-噻吩基)乙醇;2-(2-羟乙基)噻吩;2-噻吩乙醇;噻吩-2-乙醇;2-(2-噻吩)乙醇,2-(2-噻吩基)乙醇;
英文别名:2-Thiophenethanol;THIOPHENE-2-ETHYANOL;2-THIOPHENETHANOL;THIOPHENE-2-ETHANOL;2-(2-Thienyl)ethanol;2-THIENYLETHANOL;Thiopheneethanol;2-Thienylethanol;
分子式:C6H8OS
分子量:128.192
精确质量:128.03
Psa:48.47
Logp:1.2829
编号系统
MDL号:MFCD00005462
EINECS号:226-452-0
EINECS号:226-452-0
物化性质
外观与性状:透明无色至淡色的液体
密度:1.153g/mLat 25°C(lit.)
沸点:108-109°C13mm Hg(lit.)
闪点:214°F
折射率:n20/D 1.551(lit.)
水溶解性:slightly soluble
稳定性:Stable under normal temperatures and pressures.
储存条件:Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
密度:1.153g/mLat 25°C(lit.)
沸点:108-109°C13mm Hg(lit.)
闪点:214°F
折射率:n20/D 1.551(lit.)
水溶解性:slightly soluble
稳定性:Stable under normal temperatures and pressures.
储存条件:Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
安全信息
安全说明:S23-S24/25
WGK Germany:3
危险类别码:R36/37/38
海关编码:29349990
危险品标志:Xi
WGK Germany:3
危险类别码:R36/37/38
海关编码:29349990
危险品标志:Xi
生产方法及用途
生产方法
1.制法: 于装有搅拌器、温度计、滴液漏斗、回流冷凝器的反应瓶中,加入干燥的镁屑38.5g(1.58mol),无水THP100mL,一粒碘。慢慢滴入由2-溴噻吩 用作抗血栓药噻氯匹啶中间体。
用途
用作抗血栓药噻氯匹啶中间体。
1.制法: 于装有搅拌器、温度计、滴液漏斗、回流冷凝器的反应瓶中,加入干燥的镁屑38.5g(1.58mol),无水THP100mL,一粒碘。慢慢滴入由2-溴噻吩 用作抗血栓药噻氯匹啶中间体。
用途
用作抗血栓药噻氯匹啶中间体。
合成路线
上游原料
下游产品
图谱
Predict 1H proton NMR

13C NMR : in CDCl3

1H NMR : 90 MHz in CDCl3

Mass spectrum (electron ionization)

Mass

IR : liquid film
