2-Carbomethoxytropinone (2-CMT) is a commonly used organic intermediate in the synthesis of cocaine and its analogues. As of at least 1999 no reaction pathway has been discovered that synthesizes cocaine-like compounds without utilizing the reduction of 2-CMT. The structure of cocaine was discovered by Richard Willstätter in 1898 after he synthesized it from 2-carbomethoxytropinone. Although it was originally believed that 2-CMT in nature was ultimately derived from ornithine and acetic acid, subsequent research has indicated other pathways exist for the biosynthesis of 2-CMT. A β-keto ester, 2-CMT exists in equilibrium with its keto–enol tautomer.

CAS：36127-17-0
中文别名：2-甲氧羰基-3-托品酮;甲基 8-甲基-3-氧代双环[3.2.1]辛烷-2-甲酸酯;
英文别名：CARBMETHOXY-TROPINONE;CARBOMETHOXY-TROPINONE;3-Oxo-tropan-2-carbonsaeure-methylester;3-oxo-tropane-2-carboxylic acid methyl ester;
分子式：C10H15NO3
分子量：197.231
精确质量：197.105
Psa：46.61
Logp：0.1491

密度：1.173g/cm3
沸点：294.1ºC at 760mmHg
闪点：131.7ºC