Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.

CAS：152044-54-7
中文别名：帕土匹龙;
英文别名：(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;Epothilone B (EPO906,Patupilone);Epothilon B;GNF-PF-193;EpoB;Patupilone;Epothilone B;EPO906;EPO906,EpoB,Patupilone;
分子式：C27H41NO6S
分子量：507.683
精确质量：507.265
Psa：137.49
Logp：4.4775

UNII：UEC0H0URSE

外观与性状：白色粉末
密度：1.136
沸点：680.2ºC at 760mmHg
熔点：95-97ºC
闪点：365.2ºC
折射率：1.532
蒸汽压：0mmHg at 25°C