Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

CAS：189453-10-9
中文别名：埃博霉素;埃博霉素 D;
英文别名：Epothilones;Epothilon A;desoxyepothilone B;Epo A;epithilone A;Epothilone D;
分子式：C26H39NO5S
分子量：477.657
精确质量：477.255
Psa：124.96
Logp：4.8762

UNII：T0358E0YUF

密度：1.1±0.1g/cm3
沸点：657.7±55.0°Cat760mmHg
熔点：63-66°C
闪点：351.6±31.5°C
蒸汽压：0.0±2.1mmHgat25°C
折射率：1.526
储存条件：-20℃