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化合物简介

Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid tumors, such as metastatic breast cancer.

基本信息

CAS:219989-84-1
中文别名
英文别名:Ixempra;[1S-[1R*,3R*(E),7R*,10S*,11R*,12R*,16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4-aza-17-oxabicyclo[14.1.0]heptadecane-5,9-dione;16-aza-epothilone B;Ixabepilone;(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-17-oxa-4-azabicyclo[14.1.0]hepta-decane-5,9-dione;15-aza-EpoB;Azaepothilone B;Ixabepilone [INN];[14C]-Ixabepilone;(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione;
分子式:C27H42N2O5S
分子量:506.698
精确质量:506.281
Psa:140.29
Logp:4.3793

编号系统

物化性质

密度:1.122g/cm3
沸点:697.8ºC at 760mmHg
闪点:375.8ºC
折射率:1.532
蒸汽压:1.93E-20mmHg at 25°C

安全信息

生产方法及用途

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


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