Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.

CAS：1140909-48-3
中文别名：苹果酸卡博替尼;
英文别名：cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide (4-fluoro-phenyl)amide (L)-malate salt;Cabozantinib malate (XL184);Cabozantinib malate;Cabozantinib malate salt;UNII-DR7ST46X58;cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide L-malate;N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L) malate;Cometriq;Cabozantinib s-malate [USAN];XL 184;Cabozantinib L-Malate Salt;N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L)-malate salt;Cabozantinib (XL184);1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide,(2S)-2-hydroxybutanedioic acid;
分子式：C32H30FN3O10
分子量：635.593
精确质量：635.192
Psa：193.61
Logp：4.5934

UNII：DR7ST46X58

储存条件：室温，干燥，密封