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化合物简介
Cabozantinib, marketed under the trade name Cabometyx among others, is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and has been shown to reduce tumor growth, metastasis, and angiogenesis. It was discovered and developed by Exelixis Inc.
基本信息
CAS：849217-68-1
中文别名：博卡替尼;卡博替尼;N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]苯基]-N\'-(4-氟苯基)-1,1-环丙烷二甲酰胺;卡赞替尼;
英文别名：N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide;[14C]-Cabozantinib;UNII-1C39JW444G;1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;Cometriq;XL 184;Cabozantinib;
分子式：C28H24FN3O5
分子量：501.506
精确质量：501.17
Psa：98.78
Logp：5.6868
中文别名：博卡替尼;卡博替尼;N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]苯基]-N\'-(4-氟苯基)-1,1-环丙烷二甲酰胺;卡赞替尼;
英文别名：N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide;[14C]-Cabozantinib;UNII-1C39JW444G;1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;Cometriq;XL 184;Cabozantinib;
分子式：C28H24FN3O5
分子量：501.506
精确质量：501.17
Psa：98.78
Logp：5.6868
编号系统
UNII：1C39JW444G
物化性质
密度：1.397 g/cm3
沸点：758.075ºC at 760 mmHg
闪点：412.269ºC
沸点：758.075ºC at 760 mmHg
闪点：412.269ºC
安全信息
海关编码：2933499090
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
