Edaravone (brand name ラジカット, Radicut) is a nootropic and neuroprotective agent used for the purpose of aiding neurological recovery following acute brain ischemia and subsequent cerebral infarction. It acts as a potent antioxidant and strongly scavenges free radicals, protecting against oxidative stress and neuronal apoptosis. It has been marketed solely in Japan by Mitsubishi Pharma since 2001. It is also marketed in India by Edinburgh Pharmaceuticals by the brand name Arone.

CAS：89-25-8
中文别名：1-苯基-3-甲基-5-吡唑啉酮;3-甲基-1-苯基-5-吡唑啉酮;1-苯基-3-甲基-5-吡唑酮;1.3.5-吡唑酮;苯基甲基吡唑啉酮;1-苯基-3-甲基-5-吡唑啉酮(PMP);2,4-二氢-5-甲基-2-苯基-3H-吡唑-3-酮;
英文别名：3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ON;1-PHENYL-3-METHYL-5-PYRAZALONE;3-Methyl-1-phenyl-5-pyrazolone;3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;3-Methyl-1-phenyl-2-pyrazolin-5-one;c.i. developer 1;3-Methyl-1-phenyl-2-pyrazoline-5-one;1-PHENYL-3-METHYL-5-OXO-2-PYRAZOLINE;1-PHENYL-3-METHYL-2-PYRAZOLIN-5-ONE;3-METHYL-1-PHENYL-2-PYRAZOLINE-5-ONE / EDARAVONE;2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one;Edaravone (MCI-186);3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE (EDARAVONE);5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one;3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one;1-pheny-3-methyl-5-pyrazolone (PMP);1-PHENYL-3-METHYL-5-PYRAZOLONE;1-PHENYL-3-METHYL-5-PYRAZOLE;3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-;3-METHYL-1-PHENYL-2-PYRAZOLIN-5ONE;1-PHENYL-3-METHYL-5- PYRAZOLONE;5-METHYL-2-PHENYL-1,2-DIHYDROPYRAZOL-3-ONE EDARAVONE;3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE FOR SYNTHESIS;5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one;
分子式：C10H10N2O
分子量：174.199
精确质量：174.079
Psa：32.67
Logp：1.2998

MDL号：MFCD00003138

外观与性状：淡黄色结晶粉末
密度：1,12 g/cm3
沸点：287°C265mm Hg(lit.)
熔点：126-128°C(lit.)
闪点：191°C/17mm
水溶解性：3 g/L (20 ºC)
稳定性：Stable under normal temperatures and pressures.
储存条件：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

RTECS号：UQ9625000
安全说明：S26-S36
危险类别码：R36/37/38
WGK Germany：1
海关编码：2933199090
危险品标志：Xi

生产方法
用冰醋酸为原料,高温裂解得乙烯酮,经聚合得双乙烯酮,再进行氨解制得乙酰基乙酰胺. 另以苯胺为原料,在酸性条件(盐酸)下,经用NaNO2重氮化,再以亚硫酸氢铵和亚硫酸铵作还原剂进行还原,加硫酸水解生成苯肼.苯肼与乙酰基乙酰胺缩合生成本品 1.主要用于生产医药安替比林、氨基比林、安乃近.也用于染料及彩色胶片染料、农药及有机合成工业中。并可用作检测维生素B12,CO,Fe,Cu,Ni等的化学试剂。
用途
1.主要用于生产医药安替比林、氨基比林、安乃近.也用于染料及彩色胶片染料、农药及有机合成工业中。并可用作检测维生素B12,CO,Fe,Cu,Ni等的化学试剂。