11α-Hydroxyprogesterone (11α-OHP), or 11α-hydroxypregn-4-ene-3,20-dione is an endogenous steroid and metabolite of progesterone. It is a weak antiandrogen, and is devoid of androgenic, estrogenic, and progestogenic activity. It was investigated as a topical antiandrogen for the treatment of androgen-dependent skin conditions in the early 1950s, and was found to produce some benefit. In 1995, 11α-OHP, along with its analogue 11β-hydroxyprogesterone, was identified as a very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of 11β-HSD than enoxolone (glycyrrhetinic acid) or carbenoxolone in vitro (IC50 = 0.9 nM; IC50 = 5 nM in transfected cells). The compound has been found to be highly active in conferring mineralocorticoid sodium-retaining activity of corticosterone in vivo in rat bioassays and in increasing blood pressure, effects that it mediates by preventing the 11β-HSD-mediated inactivation of endogenous corticosteroids. Because of its inhibition of 11β-HSD and consequent potentiation of corticosteroids, 11α-OHP has recently been patented for the treatment of skin diseases, particularly psoriasis in combination with clobetasol propionate and minoxidil.

CAS：80-75-1
中文别名：11alpha-羟基黄体酮;11Α-羟孕酮;11ALPHA-孕酮;
英文别名：11alpha-hydroxyprogesterone;Pregn-4-ene-3,20-dione, 11-hydroxy-, (11α)-;HYDROXYPROGESTERONE,11A;DG 322B;11A-HYDROXYPROGESTERONE;4-PREGNEN-11A-OL-3,20-DIONE;Progesterone,11alpha-hydroxy;Progesterone, 11.α.-hydroxy-;11ALPHA-HYDROXYPROGESTERONE;U 0384;
分子式：C21H30O3
分子量：330.461
精确质量：330.219
Psa：54.37
Logp：3.6943

EINECS号：201-306-9

外观与性状：白色至淡米色结晶粉末
密度：1.15 g/cm3
沸点：487.4ºC at 760 mmHg
熔点：165-166ºC(lit.)
闪点：262.7ºC
折射率：1.557
储存条件：Refrigerator

安全说明：S24/25