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化合物简介
Succinimidyl-6-(biotinamido) Hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent
基本信息
CAS:72040-63-2
中文别名:6-生物素氨己酸N-琥珀酰亚胺酯;N-生物素基-6-氨基己酸琥珀酰亚胺酯;N-琥珀酰亚氨基6-生物素氨己酸;BIOTIN-AC5-OSU;N-[5-(N-琥珀酰亚胺基氧化羰基)戊基]生物素胺;生物素氨基己酸-N-羟基琥珀酰亚胺酯;生物素酰氨基己酸N-羟基琥珀酰亚胺酯;
英文别名:(2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate;
分子式:C20H30N4O6S
分子量:454.54
精确质量:454.189
Psa:159.21
Logp:1.9824
中文别名:6-生物素氨己酸N-琥珀酰亚胺酯;N-生物素基-6-氨基己酸琥珀酰亚胺酯;N-琥珀酰亚氨基6-生物素氨己酸;BIOTIN-AC5-OSU;N-[5-(N-琥珀酰亚胺基氧化羰基)戊基]生物素胺;生物素氨基己酸-N-羟基琥珀酰亚胺酯;生物素酰氨基己酸N-羟基琥珀酰亚胺酯;
英文别名:(2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate;
分子式:C20H30N4O6S
分子量:454.54
精确质量:454.189
Psa:159.21
Logp:1.9824
编号系统
MDL号:MFCD00065502
物化性质
外观与性状:白色固体
密度:1.35g/cm3
熔点:169-171°C
折射率:1.591
稳定性:Moisture Sensitive
储存条件:-20ºC
密度:1.35g/cm3
熔点:169-171°C
折射率:1.591
稳定性:Moisture Sensitive
储存条件:-20ºC
安全信息
WGK Germany:3
生产方法及用途
合成路线
-
参考文献
Wang, Tzu-Pin; Chiou, Yi-Jang; Chen, Yi; Wang, Eng-Chi; Hwang, Long-Chih; Chen, Bing-Hung; Chen, Yen-Hsu; Ko, Chun-Han Bioconjugate Chemistry, 2010 , vol. 21, # 9 p. 1642 - 1655
上游原料
下游产品
图谱
Predict 1H proton NMR
