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异炔诺酮
(8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
化合物简介
Noretynodrel (INN), or norethynodrel (USAN, BAN), also known as 17α-ethinyl-δ5,10-19-nortestosterone or as 5(10)-norethisterone, is a steroidal progestin. It was introduced in 1957 in Enovid, a combination formulation of noretynodrel and mestranol, for the treatment of gynecological and menstrual disorders. A few years later, in May 1960, Enovid was also approved as the first oral contraceptive. In addition to its progestogenic effects, noretynodrel, unlike most progestins but similarly to etynodiol diacetate, also has some estrogenic properties. It has little or no androgenic action. In accordance, noretynodrel has not been found to virilize female fetuses, in contrast to most other testosterone and 19-nortestosterone progestins such as ethisterone, norethisterone, and norethisterone acetate.
基本信息
CAS:68-23-5
中文别名:異降雄甾炔酮;
英文别名:SC-4642;Norethynodrel [Progestins];Noretinodrel [DCIT];norethynodrel;Norethynodrel;Noretynodrel;19-Norethynodrel;Norethinodrel;Enovid;Lynestrol;
分子式:C20H26O2
分子量:298.419
精确质量:298.193
Psa:37.3
Logp:3.6366
中文别名:異降雄甾炔酮;
英文别名:SC-4642;Norethynodrel [Progestins];Noretinodrel [DCIT];norethynodrel;Norethynodrel;Noretynodrel;19-Norethynodrel;Norethinodrel;Enovid;Lynestrol;
分子式:C20H26O2
分子量:298.419
精确质量:298.193
Psa:37.3
Logp:3.6366
编号系统
UNII:88181ACA0M
物化性质
密度:1.15g/cm3
沸点:441.6ºC at 760 mmHg
熔点:169-170ºC
闪点:188.2ºC
折射率:1.577
沸点:441.6ºC at 760 mmHg
熔点:169-170ºC
闪点:188.2ºC
折射率:1.577
安全信息
RTECS号:RC8980000
危险类别码:R45; R61
WGK Germany:3
危险类别码:R45; R61
WGK Germany:3
生产方法及用途
合成路线
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参考文献
US2691028 , ;
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
