Dimethyl fumarate (DMF) is the methyl ester of fumaric acid. DMF was initially recognized as a very effective hypoxic cell radiosensitizer. Later, DMF combined with three other fumaric acid esters (FAE) was licensed in Germany as oral therapy for psoriasis (trade name Fumaderm). Other diseases, such as necrobiosis lipoidica, granuloma annulare, and sarcoidosis were also found to respond to treatment with DMF in case reports or small patient series. Phase III clinical trials found that DMF (BG-12) successfully reduced relapse rate and increased time to progression of disability in multiple sclerosis (trade name Tecfidera). DMF is thought to have immunomodulatory properties without significant immunosuppression.

CAS：624-49-7
中文别名：(E)-2-丁烯二酸二甲酯;防霉保鲜剂;霉克星1号;延胡索酸二甲酯;反丁烯二酸二甲酯;富马酸二甲;
英文别名：Dimethyl fumarate;2-Butenedioic acid (E)-, dimethyl ester;Dimethyl Fumarate;
分子式：C6H8O4
分子量：144.125
精确质量：144.042
Psa：52.6
Logp：-0.1114

EINECS号：210-848-5
MDL号：MFCD00064438

外观与性状：细白色结晶粉末
密度：1,37 g/cm3
沸点：192-193°C(lit.)
熔点：102-106°C(lit.)
闪点：192-193°C
折射率：1.4037 (110.7ºC)
稳定性：Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
储存条件：Store at RT.

RTECS号：EM6125000
安全说明：S26-S36/37/39
危险类别码：R21; R36/37/38
WGK Germany：1
海关编码：2917140000
危险品标志：Xn

生产方法
(1)富马酸酯化法。直接以富马酸为原料,在催化剂存在下与甲醇一步合成DMF。催化剂有三氟化硼、六水氯化铁(FeCl3·6H2O)、硫酸或磷酸,收率高达92%。也可以阳离子树脂催化剂,采用催化精馏技术,于80-85℃下酯化反应5h。 主要用作食品及饲料添加剂,在饲料中添加0.2%就有明显效果,一般剂量为500～800mg/kg。还用作溶剂、防霉保鲜剂。
用途
主要用作食品及饲料添加剂,在饲料中添加0.2%就有明显效果,一般剂量为500～800mg/kg。还用作溶剂、防霉保鲜剂。