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化合物简介
Methyl 6-(Hydroxymethyl)-2-pyridinecarboxylate is a chemical compound used in the synthesis of Losartan derivatives as AT1 antagonists in the preparation of antihypertensive agents. Also used to prepare telomerase inhibitors for in vivo inhibitory activity.
基本信息
CAS：39977-44-1
中文别名：6-羟甲基-吡啶-2-甲酸甲酯;
英文别名：2-PYRIDINECARBOXYLIC ACID,6-(HYDROXYMETHYL)-,METHYL ESTER;Methyl-6-hydroxymethyl-2-carboxylate pyridine;6-hydroxymethylpyridine-2-carboxylic acid methyl ester;methyl 6-(hydroxymethyl)picolinate;6-(hydroxymethyl)-2-pyridinecarboxylic acid methyl ester;2-hydroxymethylpyridine-6-carboxylic acid methyl ester;methyl 6-hydroxymethylpyridine-2-carboxylate;
分子式：C8H9NO3
分子量：167.162
精确质量：167.058
Psa：59.42
Logp：0.3605
中文别名：6-羟甲基-吡啶-2-甲酸甲酯;
英文别名：2-PYRIDINECARBOXYLIC ACID,6-(HYDROXYMETHYL)-,METHYL ESTER;Methyl-6-hydroxymethyl-2-carboxylate pyridine;6-hydroxymethylpyridine-2-carboxylic acid methyl ester;methyl 6-(hydroxymethyl)picolinate;6-(hydroxymethyl)-2-pyridinecarboxylic acid methyl ester;2-hydroxymethylpyridine-6-carboxylic acid methyl ester;methyl 6-hydroxymethylpyridine-2-carboxylate;
分子式：C8H9NO3
分子量：167.162
精确质量：167.058
Psa：59.42
Logp：0.3605
编号系统
MDL号：MFCD03840850
物化性质
密度：1.244g/cm3
沸点：327.3ºC at 760mmHg
闪点：151.7ºC
折射率：1.546
沸点：327.3ºC at 760mmHg
闪点：151.7ºC
折射率：1.546
安全信息
海关编码：2933399090
生产方法及用途
合成路线
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参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley Patent: WO2013/102145 A1, 2013 ; Location in patent: Paragraph 0333 ;
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
