4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents.

CAS：327-78-6
中文别名：4-氯-3-三氟甲基苯基异氰酸酯;索拉非尼中间体3;异氰酸4-氯-3-(三氟甲基)苯酯;
英文别名：4-Chloro-3-(trifluoromethyl)phenyl Isocyanate;3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE;Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester;1-chloro-4-isocyanato-2-(trifluoromethyl)benzene;4-Chloro-3-(trifluoromethyl)phenylisocyanate;4-Cl-3CF3-phenyl isocyanate;Sorafenib intermediate 3;1-chloro-4-isocyanato-2-trifluoromethylbenzene;
分子式：C8H3ClF3NO
分子量：221.564
精确质量：220.986
Psa：29.43
Logp：3.3261

MDL号：MFCD00013874

外观与性状：白色至淡黄色低熔点固体,粉末或大块
密度：1.4 g/cm3
沸点：86-90°C14mm Hg(lit.)
熔点：40-42°C(lit.)
闪点：211°F
折射率：1.487

安全说明：S7-S26-S27-S37/39-S36/37/39-S45-S23
WGK Germany：3
危险类别码：R20/21/22; R36/37/38
危险品运输编码：UN 2206 6.1/PG 3
海关编码：2929109000
危险类别：6.1
包装等级：III
危险品标志：Xn

用途
是索拉菲尼中间体。