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化合物简介
Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).
基本信息
CAS：22788-18-7
中文别名：
英文别名：Carboxyphosphamide;Carboxyphosphamid;2-Carboxyethyl-N,N-bis(2-chloroethyl)phosphorodiamidate;N,N-Bis-(2-chlorethyl)-diamidophosphorsaeure-(2-carboxyethylester) (freie Saeure);Carboxycyclophosphamide;Asta 5754;carboxyethylphosphoramide mustard;Hydracrylic acid,N,N-bis(2-chloroethyl)phosphorodiamidate;O-carboxyethylphosphoramide mustard;O-(2-Carboxyethyl) N,N-bis(2-chloroethyl)phosphorodiamidate;
分子式：C7H15Cl2N2O4P
分子量：293.085
精确质量：292.015
Psa：102.67
Logp：2.0244
中文别名：
英文别名：Carboxyphosphamide;Carboxyphosphamid;2-Carboxyethyl-N,N-bis(2-chloroethyl)phosphorodiamidate;N,N-Bis-(2-chlorethyl)-diamidophosphorsaeure-(2-carboxyethylester) (freie Saeure);Carboxycyclophosphamide;Asta 5754;carboxyethylphosphoramide mustard;Hydracrylic acid,N,N-bis(2-chloroethyl)phosphorodiamidate;O-carboxyethylphosphoramide mustard;O-(2-Carboxyethyl) N,N-bis(2-chloroethyl)phosphorodiamidate;
分子式：C7H15Cl2N2O4P
分子量：293.085
精确质量：292.015
Psa：102.67
Logp：2.0244
编号系统
UNII：DP4677AX41
物化性质
密度：1.444g/cm3
沸点：447.4ºC at 760mmHg
闪点：224.3ºC
折射率：1.519
蒸汽压：2.99E-09mmHg at 25°C
沸点：447.4ºC at 760mmHg
闪点：224.3ºC
折射率：1.519
蒸汽压：2.99E-09mmHg at 25°C
安全信息
海关编码：2931900090
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
