4-Hydroxycyclophosphamide is in the class of oxazaphosphorine compounds, and is the main, active metabolite of cyclophosphamide and of mafosfamide after they partially metabolized by cytochrome P450. It is then partially tautomerized into aldophosphamide, which, in turn, easily enters live cells and then is partially detoxified into inactive carboxycyclophosphamide by the enzyme ALDH, but partially is hydrolyzed by another cell's enzyme phosphatase to the two directly cytotoxic metabolites - phosphoramide mustard and acrolein.

CAS：40277-05-2
中文别名：
英文别名：4-Hydroxycyclophosphamid;4-Hydroperoxydechlorocyclophosphamide;4-Hydroxycyclophosphamide;2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ⁵-oxazaphosphinan-4-ol;4-OH cyclophosphamide;
分子式：C7H15Cl2N2O3P
分子量：277.085
精确质量：276.02
Psa：71.61
Logp：1.5312

MDL号：MFCD00869529

密度：1.42g/cm3
沸点：387.1ºC at 760 mmHg
闪点：187.9ºC
折射率：1.527

海关编码：2934999090