Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

CAS：187960-08-3
中文别名：
英文别名：Bonistein-d4;GeniVida-d4;Baichanin A-d4;Prunetol-d4;2\',3\',5\',6\'-tetradeuterogenistein;Sophoricol-d4;4\',5,7-Trihydroxyisoflavone-d4;Genisteol-d4;
分子式：C15H6D4O5
分子量：274.262
精确质量：274.078
Psa：90.9
Logp：2.5768

密度：1.5±0.1g/cm3
沸点：555.5±50.0°Cat760mmHg
闪点：217.1±23.6°C
蒸汽压：0.0±1.6mmHgat25°C
折射率：1.732
储存条件：-20°C，密闭，干燥