Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

CAS：446-72-0
中文别名：染料木黄酮;金雀异黄素;4\',5,7-三羟基异黄酮;5,7-二羟基-3-(4-羟苯基)-4H-1-苯并吡喃-4-酮;三羟基异黄酮;金雀异黄酮;
英文别名：5,7,4\'-trihydroxyisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4\',5,7-Trihydroxyisoflavone;Genistein;GeniVida;BonisteinNPI 031L;prunetol;sophoricol;4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-;genisteol;GLYCITEN;
分子式：C15H10O5
分子量：270.237
精确质量：270.053
Psa：90.9
Logp：2.5768

MDL号：MFCD00016952

外观与性状：黄色结晶固体
密度：1.548 g/cm3
沸点：555.5ºC at 760 mmHg
熔点：297-298 °C
闪点：217.1ºC
折射率：1.732
水溶解性：insoluble
储存条件：-20ºC
蒸汽压：6E-13mmHg at 25°C

RTECS号：NR2392000
安全说明：S26-S24/25-S22
危险类别码：R36/38
WGK Germany：3
海关编码：2932999099
危险品标志：Xi
危险标志：GHS07
信号词：Warning
危险性描述：H302

生产方法
暂无 有抗肿瘤、降血脂作用，还有雌激素样作用。
用途
有抗肿瘤、降血脂作用，还有雌激素样作用。