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DELTORPHIN I
(3S)-3-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
化合物简介
Deltorphin I, also known as [D-Ala2]deltorphin I or deltorphin C, is a naturally-occurring, exogenous opioid heptapeptide and hence, exorphin, with the amino acid sequence Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2. While not known to be endogenous to humans or other mammals, deltorphin I, along with the other deltorphins and the dermorphins, is produced naturally in the skin of species of Phyllomedusa, a genus of frogs native to South and Central America. Deltorphin possesses very high affinity and selectivity as an agonist for the δ-opioid receptor, and on account of its unusually high blood-brain-barrier penetration rate, produces centrally-mediated analgesic effects in animals even when administered peripherally.
基本信息
CAS：122752-15-2
中文别名：
英文别名：deltorphin I;H-Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2;Deltorphin C;Tyr-D-Ala-Phe-Asp-Val-Val-Cly-NH2;
分子式：C37H52N8O10
分子量：768.856
精确质量：768.381
Psa：301.24
Logp：2.0828
中文别名：
英文别名：deltorphin I;H-Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2;Deltorphin C;Tyr-D-Ala-Phe-Asp-Val-Val-Cly-NH2;
分子式：C37H52N8O10
分子量：768.856
精确质量：768.381
Psa：301.24
Logp：2.0828
编号系统
物化性质
密度：1.284g/cm3
沸点：1242.4ºC at 760mmHg
闪点：705.2ºC
折射率：1.578
储存条件：-15ºC
蒸汽压：0mmHg at 25°C
沸点：1242.4ºC at 760mmHg
闪点：705.2ºC
折射率：1.578
储存条件：-15ºC
蒸汽压：0mmHg at 25°C
