化学科研者一站式服务平台
化合物简介
Dexpramipexole (KNS-760704) is a drug that was investigated by Knopp Biosciences and Biogen Idec for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. The drug failed to show efficacy in terms of function or survival in a Phase III study of patients with ALS.
基本信息
CAS：104632-28-2
中文别名：(R)-普拉克索二盐酸化物;(R)-普拉克索;
英文别名：(6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole;Dexpramipexole;(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine;(6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine;(R)-Pramipexole Dihydrochloride;Pramipexole [USAN:INN];(R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole;
分子式：C10H19Cl2N3S
分子量：284.249
精确质量：283.068
Psa：83.52
Logp：4.3849
中文别名：(R)-普拉克索二盐酸化物;(R)-普拉克索;
英文别名：(6R)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole;Dexpramipexole;(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine;(6R)-4,5,6,7-tetrahydro-N6-propylbenzothiazole-2,6-diamine;(R)-Pramipexole Dihydrochloride;Pramipexole [USAN:INN];(R)-(+)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole;
分子式：C10H19Cl2N3S
分子量：284.249
精确质量：283.068
Psa：83.52
Logp：4.3849
编号系统
物化性质
熔点：270-272ºC
安全信息
海关编码：2934999090
生产方法及用途
合成路线
-
参考文献
WO2010/22140 A1, ; Page/Page column 100-101 ;
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
