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化合物简介

Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given to prevent and treat pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly named Pneumocystis carinii), a severe interstitial type of pneumonia often seen in patients with human immunodeficiency virus (HIV) infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma brucei gambiense (West African trypanosomiasis).

基本信息

CAS:100-33-4
中文别名:4,4\'-二脒基二苯氧基戊烷;
英文别名:Pentamidine;4,4\'-(Pentane-1,5-diylbis(oxy))dibenzimidamide;
分子式:C19H24N4O2
分子量:340.419
精确质量:340.19
Psa:118.2
Logp:4.4829

编号系统

EINECS号:202-841-0

物化性质

外观与性状:橙色固体
密度:1.2g/cm3
沸点:539.4ºC at 760mmHg
熔点:186ºC (dec.)
闪点:280ºC
稳定性:Stable under normal temperatures and pressures.
储存条件:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
蒸汽压:1.06E-11mmHg at 25°C

安全信息

危险品运输编码:UN 3249
海关编码:2925290090
危险类别:6.1(b)
包装等级:III

生产方法及用途

合成路线

上游原料

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图谱

1H NMR : Predict


13C NMR : Predict


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