Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. - Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. Recently, a series of selective mACh-receptor antagonists based on the Diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials* .

CAS：972-02-1
中文别名：1,1-二苯基-4-(1-哌啶基)-1-丁醇;二苯哌丁醇;
英文别名：defenidol;Difenidolo;1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;Diphenidol;1,1-diphenyl-4-piperidin-1-yl-butan-1-ol;Nometic;Difenidolo [DCIT];Avomol;Cephadol;DIPHENIDOL;Vontrol;Difenidolum;1,1-diphenyl-4-piperidylbutanol;Difenidol;
分子式：C21H27NO
分子量：309.445
精确质量：309.209
Psa：23.47
Logp：4.1265

UNII：NQO8R319LY

密度：1.066 g/cm3
沸点：473.3ºC at 760 mmHg
熔点：105ºC
闪点：233.5ºC

海关编码：2933399090