o-Anisidine (2-anisidine) is a yellow liquid with a melting point of -1 to 5 °C and a density of 1.09 g/cm3. The vapor pressure is 0.05 mbar at 20 °C but increases greatly with temperature. It has an aromatic smell and is well absorbed by inhalation, oral ingestion and skin contact. o-Anisidine is a very toxic agent that causes blood, enzyme and nerve damage with cyanosis and the danger of suffocation. The agent is an experimental carcinogen and is strongly suspected to be a human carcinogen also. o-Anisidine has dangerous pollutant properties for water. Non-wastewaters from the production of dyes containing o-Anisidine are listed as RCRA hazardous waste, with the code K181. o-Anisidine is used in the manufacture of dyes. Workers in the dye industry may be occupationally exposed to it. Acute (short-term) exposure to o-anisidine results in skin irritation in humans. Workers exposed to o-anisidine by inhalation for 6 months developed headaches, vertigo, and effects on the blood. Animal studies have reported effects on the blood from chronic (long-term) dermal exposure to o-anisidine. No information is available on the reproductive, developmental, or carcinogenic effects of o-anisidine in humans. Animal studies have reported tumors of the urinary bladder from oral exposure to o-anisidine. EPA has not classified o-anisidine for carcinogenicity. The International Agency for Research on Cancer (IARC) has classified o-anisidine as a Group 2B, possible human carcinogen.

CAS：90-04-0
中文别名：邻氨基苯甲醚;2-茴香胺;2-甲氧基苯胺;邻茴香胺;
英文别名：Benzenamine, 2-methoxy-;o-Methoxyphenylamine;1-amino-2-methoxy-benzene;ORTHO ANISIDINE;2-methoxy-phenylamine;2-ANISIDINE;2-AMINOANISOLE;2-methoxybenzenamine;2-methoxyaniline;o-Amnoanisde;2-Anisidin;O-ANISOLE;O-AMINOANISOLE;
分子式：C7H9NO
分子量：123.152
精确质量：123.068
Psa：35.25
Logp：1.8586

EINECS号：201-963-1
MDL号：MFCD00007688

外观与性状：淡黄色液体，暴露在空气中变成褐色
密度：1.092g/mLat 25°C(lit.)
沸点：225°C(lit.)
熔点：3-6°C(lit.)
闪点：210°F
折射率：n20/D 1.574(lit.)
水溶解性：13 g/L (20 ºC)
稳定性：Stable. Incompatible with strong oxidizing agents, acid anhydrides, chloroformates, acids, some plastics, rubber. Air sensitive.
储存条件：库房通风低温干燥,与食品原料分开储运

RTECS号：BZ5410000
安全说明：S53-S45
危险类别码：R23/24/25; R45; R68
WGK Germany：3
危险品运输编码：UN 2431 6.1/PG 3
海关编码：2922199090
危险类别：6.1
包装等级：III
危险品标志：T

生产方法
1.由邻硝基苯甲醚还原而得，邻硝基苯甲醚可由邻硝基氯甲苯氧基化得到[91-23-6]，还原剂可采用硫化钠或铁粉。另外，也可由邻硝基苯酚经甲基化、还原来制取邻甲氧基苯胺。原料消耗定额：邻硝基氯苯1301kg/t、甲醇（98%）395kg/t、硫化钠（60%）1128kg/t、烧碱（96%）457kg/t。 用作染料、香料及医药中间体。
用途
用作染料、香料及医药中间体。