Tropisetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. The drug is available in a 5mg oral preparation or in 2mg intravenous form. It is marketed by Novartis in Europe, Australia, New Zealand, Japan, South Korea and the Philippines as Navoban, but is not available in the U.S. It is also available from Novell Pharmaceutical Laboratories and marketed in several Asian countries as Setrovel.

CAS：89565-68-4
中文别名：1H-吲哚-3-羧酸-8-甲基-8-氮杂双环桥[3,2,1]辛-3-基酯;托普西隆;3-吲哚甲酸-(8-甲基-8-氮杂双环[3.2.1]辛-3-基)酯;吲哚-3-甲酰氯;1ΑH,5ΑH-托烷-3Α-基吲哚-3-羧酸酯;
英文别名：TROPISHTRON HYDROCHLORIDE;Indole-3-carbonyl chloride;SS-TROPISETRON;icf205-930;3-Tropanylindole-3-carboxylate;TROPICACID;ICS 205-930;Tropisetron;
分子式：C17H21ClN2O2S
分子量：352.879
精确质量：352.101
Psa：83.8
Logp：4.3864

UNII：6I819NIK1W

外观与性状：白色固体
密度：1.26
沸点：448.5ºC at 760 mmHg
熔点：201-202 °C
闪点：225ºC
折射率：1.644
储存条件：2-8ºC

WGK Germany：3

生产方法
吲哚-3-甲酸溶于甲苯,加入亚硫酰氯,搅拌回流反应,蒸出部分甲苯,在50℃缓慢加入托品醇的甲苯溶液反应,蒸出甲苯,冷却,加入乙酸乙酯和水,搅拌,滴加氨水调节pH值,分出有机层,干燥后蒸出乙酸乙酯;得到的物质溶于乙醇,通入氯化氢气体至pH为3,过滤,浓缩,冷却即得托烷司琼。 为5-羟色胺拮抗药。
用途
为5-羟色胺拮抗药。