Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. However, development was halted and it was not marketed. Perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone. It was found to be both more potent and more selective in comparison and was commercialized instead.

CAS：87691-91-6
中文别名：
英文别名：Tiospirona [Spanish];tiaspirone;Tiospirone [INN];Tiospironum [Latin];[14C]-Tiospirone;Tiospironum;Tiospirona;8-{4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl}-8-azaspiro[4.5]decane-7,9-dione;8-Azaspiro(4,5)decane-7,9-dione,8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl);TIOSPIRONE;
分子式：C24H32N4O2S
分子量：440.601
精确质量：440.225
Psa：84.99
Logp：3.8487

UNII：35C6UMO5SR

密度：1.29g/cm3
沸点：600.9ºC at 760 mmHg
闪点：317.2ºC
折射率：1.652