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  • 綠膿素

    5-methylphenazin-1-one

化合物简介

Pyocyanin (PCN−) is one of the many toxins produced and secreted by the Gram negative bacterium Pseudomonas aeruginosa. Pyocyanin is a blue, secondary metabolite with the ability to oxidise and reduce other molecules and therefore can kill microbes competing against P. aeruginosa as well as mammalian cells of the lungs which P. aeruginosa has infected during cystic fibrosis. Since pyocyanin is a zwitterion at blood pH, it is easily able to cross the cell membrane. There are three different states in which pyocyanin can exist; oxidized, monovalently reduced or divalently reduced. Mitochondria play a huge role in the cycling of pyocyanin between its redox states. Due to its redox-active properties, pyocyanin generates reactive oxygen species.

基本信息

CAS:85-66-5
中文别名
英文别名:Sanasin;5-methyl-5H-phenazin-1-one;PYOCYANINE;Phenazinium, 1-hydroxy-5-methyl-, hydroxide, inner salt;1-hydroxy-5-methyl-phenazinium betaine;Pyocyanin;1-hydroxy-5-methylphenazine;Sanazin;Pyrocyanine;
分子式:C13H10N2O
分子量:210.231
精确质量:210.079
Psa:39.83
Logp:2.3563

编号系统

物化性质

密度:1.24g/cm3
沸点:403.3ºC at 760 mmHg
闪点:197.7ºC
折射率:1.665

安全信息

海关编码:2933990090
危险性描述:H302; H318
危险标志:GHS05, GHS07
信号词:Danger
危险性防范说明:P280; P305 + P351 + P338

生产方法及用途

合成路线

上游原料

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图谱

13C NMR : Predict


1H NMR : Predict


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