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2-溴-1-(4-氟苯基)-1-丁酮
N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)-oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
化合物简介
Foretinib is an experimental drug candidate for the treatment of cancer. It was discovered by Exelixis and is under development by GlaxoSmithKline. About 10 Phase II clinical trials have been run. As of October 2015[update] no phase III trials are registered.
基本信息
CAS：849217-64-7
中文别名：N-[3-氟-4-[[6-甲氧基-7-[[3-(吗啉-4-基)丙基]氧]喹啉-4-基]氧]苯基]-N-(4-氟苯基)环丙烷-1,1-二甲酰胺;
英文别名：4-(4-(o-Methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-1-butanol dihydrochloride;4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol dihydrochloride;Foretinib;4-(4-Hydroxy-4-(3,4,5-trimethoxyphenyl)butyl)-1-(o-methoxyphenyl)piperazine dihydrochloride;N1-{3-fluoro-4-[(6-(methyloxy)-7-{[3-(4-morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1\'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide;N-[3-fluoro-4-([6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl]oxy)phenyl]-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;1-Butanol,4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-,dihydrochloride;
分子式：C34H34F2N4O6
分子量：632.654
精确质量：632.245
Psa：116.45
Logp：5.9834
中文别名：N-[3-氟-4-[[6-甲氧基-7-[[3-(吗啉-4-基)丙基]氧]喹啉-4-基]氧]苯基]-N-(4-氟苯基)环丙烷-1,1-二甲酰胺;
英文别名：4-(4-(o-Methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-1-butanol dihydrochloride;4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol dihydrochloride;Foretinib;4-(4-Hydroxy-4-(3,4,5-trimethoxyphenyl)butyl)-1-(o-methoxyphenyl)piperazine dihydrochloride;N1-{3-fluoro-4-[(6-(methyloxy)-7-{[3-(4-morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1\'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide;N-[3-fluoro-4-([6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl]oxy)phenyl]-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;1-Butanol,4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-,dihydrochloride;
分子式：C34H34F2N4O6
分子量：632.654
精确质量：632.245
Psa：116.45
Logp：5.9834
编号系统
UNII：81FH7VK1C4
物化性质
密度：1.372g/cm3
沸点：828.475ºC at 760 mmHg
闪点：454.846ºC
折射率：1.649
沸点：828.475ºC at 760 mmHg
闪点：454.846ºC
折射率：1.649
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
