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  • 多他利嗪

    1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine

化合物简介

Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.

基本信息

CAS:84625-59-2
中文别名
英文别名:DOTARIZINE;Dotarizinum;Dotarizina;
分子式:C29H34N2O2
分子量:442.592
精确质量:442.262
Psa:24.94
Logp:4.9494

编号系统

物化性质

密度:1.122 g/cm3
沸点:557.4ºC at 760 mmHg
熔点:100-101ºC
闪点:147.9ºC
折射率:1.587

安全信息

海关编码:2933599090

生产方法及用途

合成路线

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图谱

13C NMR : Predict


1H NMR : Predict


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