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  • 吉哌隆

    4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione

化合物简介

Gepirone (INN) (current developmental code name TGFK07AD; proposed brand name Travivo) or gepirone hydrochloride (USAN) is an antidepressant and anxiolytic drug of the azapirone group that was synthesized by Bristol-Myers Squibb in 1986 and has been under development for the treatment of depression but has yet to be marketed. Like other azapirones, it acts as a selective partial agonist of the 5-HT1A receptor. Gepirone has been under development in the U.S. in an extended release form (referred to as gepirone ER), but despite completing phase III clinical trials and demonstrating efficacy, it has been rejected multiple times by the FDA during the drug approval process.

基本信息

CAS:83928-76-1
中文别名
英文别名:4,4-dimethyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]piperidine-2,6-dione;
分子式:C19H29N5O2
分子量:359.466
精确质量:359.232
Psa:69.64
Logp:1.4948

编号系统

MDL号:MFCD00868196

物化性质

密度:1.1±0.1g/cm3
沸点:562.3±60.0°Cat760mmHg
闪点:293.8±32.9°C
蒸汽压:0.0±1.5mmHgat25°C
折射率:1.542
储存条件:2-8°C,保存于惰性气体中

安全信息

海关编码:2933990090

生产方法及用途

合成路线

上游原料

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图谱

13C NMR : Predict


1H NMR : Predict


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