Lupitidine (INN) (code name SKF-93479), or lupitidine hydrochloride (USAN), is a long-acting H2 receptor antagonist developed by Smith, Kline & French and described as an antiulcerogenic that was never marketed. It was shown to inhibit nocturnal gastric acid secretion and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.

CAS：83903-06-4
中文别名：
英文别名：2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone;LUPITIDINE;Lupitidine [INN];Lupitidinum;2-[2-(5-dimethylaminomethyl-furan-2-ylmethylthio)ethylamino]-5-(6-methyl-pyridin-3-ylmethyl)-4-pyrimidone;2-[[2-[[[5-[(dimethylamino)methyl]-furan-2-yl]methyl]thio]ethyl]amino]-5-(6-methyl-3-pyridinyl)methyl-4(1H)-pyrimidinone;UNII-WF028DWK9N;Lupitidinum [Latin];2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidinone;2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-5-(6-methyl-pyridin-3-ylmethyl)-4-pyrimidone;
分子式：C21H27N5O2S
分子量：413.536
精确质量：413.189
Psa：112.35
Logp：3.137

UNII：WF028DWK9N

密度：1.25g/cm3
沸点：559.4ºC at 760 mmHg
闪点：292.1ºC
折射率：1.629