Perindopril is a long-acting ACE inhibitor used to treat high blood pressure, heart failure, or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (Aceon). According to the Australian government's Pharmaceutical Benefits Scheme website, based on data provided to the Australian Department of Health and Aging by the manufacturer, perindopril arginine and perindopril erbumine are therapeutically equivalent and may be interchanged without differences in clinical effect. However, the dose prescribed to achieve the same effect differs due to different molecular weights for the two forms.

CAS：82834-16-0
中文别名：培垛普利;[2S-[1-[R^^,(R^^)],2Α,3ΑΒ,7ΑΒ]]-1-[2-[[1-(乙氧羰基)丁基]氨基]-1-氧丙基]八氢-1H-吲哚-2-羧酸;1-[2-[[(1S)-(1-乙氧羰基)丁基]氨基]丙酰]-(2S,3aS,7aS)-八氢吲哚-2-羧酸;
英文别名：Procaptan;McN-A-2833-109;S-9490,McNA-2833;S-9490;Perindopril;MCNA-2833;Coversyl;S-9490-3;
分子式：C19H32N2O5
分子量：368.468
精确质量：368.231
Psa：95.94
Logp：2.2694

UNII：Y5GMK36KGY

外观与性状：白色粉末
密度：1.15 g/cm3
沸点：537.4ºC at 760 mmHg
熔点：100-101°C
闪点：278.8ºC

安全说明：S24/25
WGK Germany：3
危险类别码：R20/21/22
危险品标志：Xi

生产方法
化合物(I)和化合物(Ⅱ)进行缩合，然后水解即可得到培垛普利。化合物(Ⅰ)可由化合物(Ⅲ)出发，经酯化、还原、水解再酯化得到。化合物(Ⅱ)可由化合物(Ⅳ)和化合物(Ⅶ)进行还原氨解反应得到，收率52%。(可参见Lane C F．Synthesis，1975，135～1 用于治疗高血压、充血性心力衰竭等病症。
用途
用于治疗高血压、充血性心力衰竭等病症。