Cabergoline (brand names Caberlin, Dostinex and Cabaser), an ergot derivative, is a potent dopamine receptor agonist on D2 receptors. Rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph (prolactin) cells. It is frequently used as a first-line agent in the management of prolactinomas due to its higher affinity for D2 receptor sites, less severe side effects, and more convenient dosing schedule than the older bromocriptine.

CAS：81409-90-7
中文别名：6-烯丙基-N-[3-(二甲基氨基)丙基]-N-(乙基氨基甲酰基)麦角林-8-甲酰胺;1-[(6-Allylergoline-8β-yl)carbonyl]-1-[3-(dimethylamino)-propyl]-3-ethylurea;-烯丙基-N-[3-(二甲基氨基)丙基]-N-(乙基氨基甲酰基)麦角林-8-甲酰胺;(8Β)-N-[3+(二甲氨基)丙基]-N-[(乙氨基)羧基]-6-(2-丙烯基)麦角林-8-羧酰胺;
英文别名：Dostinex(R);Cabaseril;(6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;Cabergolina;N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-8g-ergoline-8-carboxamide;Dostinex;Cabergolinum;Cabaser;Cabergolinum [Latin];Galastop(R);Galastop;Cabergolina [Spanish];
分子式：C26H37N5O2
分子量：451.604
精确质量：451.295
Psa：71.68
Logp：3.5227

UNII：LL60K9J05T

外观与性状：白色结晶固体
密度：1.156 g/cm3
熔点：102-104°C
折射率：1.594
储存条件：Store at +4ºC

RTECS号：ZB3200000
安全说明：S8; S24/25; S46
危险类别码：R37; R43
危险品运输编码：UN 2210
危险类别：9
包装等级：III
危险品标志：Xi
危险性防范说明：P261; P305 + P351 + P338
危险性描述：H302; H315; H319; H335
信号词：Warning
危险标志：GHS07

生产方法
6-(2-丙烯基)麦角林-8β-羧酸(Ⅰ)和碳化二亚胺在四氢呋喃中反应,可得卡麦角林。 长效多巴胺拮抗剂。用于治疗原发性或曲垂体瘤所引起的高催乳素症。
用途
长效多巴胺拮抗剂。用于治疗原发性或曲垂体瘤所引起的高催乳素症。