Fluticasone propionate belongs to a class of drugs known as corticosteroids, specifically glucocorticoids, which are hormones that predominantly affect the metabolism of carbohydrates and, to a lesser extent, fat and protein. It is used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohn's disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis.

CAS：80474-14-2
中文别名：(6Α,11Β,16Α,17Α)-6,9-二氟-11-羟基-16-甲基-3-氧代17-(1-氧丙氧基)雄甾-1,4-二烯-17-硫代羧酸S-(氟甲基)酯;6,9-二氟-11羟基甲基氧代(氧代丙氧基)雄甾,二烯硫代羧酸-S-氟甲酯;氟替卡松丙酸酯;
英文别名：FLIXONASE;FLIXOTIDE;FLUNASE;Flutide N;fluticasone propionate;Zoflut;FLOVENT;CUTIVATE;flutide;FLONASE;Fluticasone propionate;
分子式：C25H31F3O5S
分子量：500.571
精确质量：500.184
Psa：105.97
Logp：4.43

MDL号：MFCD00866007

外观与性状：结晶固体
密度：1.32 g/cm3
沸点：568.3ºC at 760 mmHg
熔点：275 °C
闪点：297.5ºC
折射率：31 ° (C=1, Dioxane)
储存条件：Store in original container in a cool dark place.

RTECS号：BV7980000
安全说明：S22-S24/25
WGK Germany：2
海关编码：2937229000

生产方法
化合物(Ⅰ)先和N,N-二甲基硫代氯甲酰胺反应后,再水解得到相应的硫代羧酸(Ⅱ),然后和-溴-氟甲烷反应酯化,得丙酸氟替卡松。 为局部有效的皮质甾体药物。用于抗过敏反应。
用途
为局部有效的皮质甾体药物。用于抗过敏反应。