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化合物简介
Iloprost is a drug used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and other diseases in which the blood vessels are constricted and blood can't flow to the tissues. This damages the tissues and causes high blood pressure. Iloprost works by opening (dilating) the blood vessels to allow the blood to flow through again. It was developed by the pharmaceutical company Schering AG and is marketed by Bayer Schering Pharma AG in Europe and Actelion Pharmaceuticals in the USA.
基本信息
CAS:78919-13-8
中文别名:
英文别名:Ataprost [INN];Ataprostum;Iloprost;5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octa-3-ylidene)-pentanoic acid;5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-5-octen-6-inyl]-bicyclo[3.3.0]-octan-3-ylidene}pentenoic acid;Pentanoic acid,5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-,(3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha));Ataprost;Ataprostum [INN-Latin];
分子式:C22H32O4
分子量:360.487
精确质量:360.23
Psa:77.76
Logp:3.5413
中文别名:
英文别名:Ataprost [INN];Ataprostum;Iloprost;5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octa-3-ylidene)-pentanoic acid;5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-5-octen-6-inyl]-bicyclo[3.3.0]-octan-3-ylidene}pentenoic acid;Pentanoic acid,5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-,(3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha));Ataprost;Ataprostum [INN-Latin];
分子式:C22H32O4
分子量:360.487
精确质量:360.23
Psa:77.76
Logp:3.5413
编号系统
UNII:JED5K35YGL
物化性质
外观与性状:无色油状
密度:1.21g/cm3
沸点:539.2ºC at 760 mmHg
熔点:115.7ºC
闪点:294ºC
折射率:1.629
储存条件:Desiccate at -20ºC
密度:1.21g/cm3
沸点:539.2ºC at 760 mmHg
熔点:115.7ºC
闪点:294ºC
折射率:1.629
储存条件:Desiccate at -20ºC
安全信息
海关编码:2918199090
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
