Chlortalidone (INN/BAN) or chlorthalidone (USAN) is a diuretic drug used to treat hypertension, originally marketed as Hygroton in the USA. It is described as a thiazide diuretic (or, rather, a thiazide-like diuretic because it acts similarly to the thiazides but does not contain the benzothiadiazine molecular structure). Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. It is often used in the management of hypertension and edema.

CAS：77-36-1
中文别名：氯塞酮;
英文别名：2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonamide;2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide;
分子式：C14H11ClN2O4S
分子量：338.766
精确质量：338.013
Psa：117.87
Logp：3.0341

MDL号：MFCD00036257

外观与性状：白色至淡黄色-白色结晶粉末无气味的
密度：1.601g/cm3
熔点：265-267ºC (dec.)
折射率：1.694
稳定性：Stable under normal temperatures and pressures.
储存条件：2-8ºC

安全说明：S22; S24/25
海关编码：2935009090

生产方法
由苯酐与氯苯加成、经硝化、还原得邻(3-氨基-4-氯苯甲酰)苯甲酸,然后经重氮化、置换、氯磺化,最后经环合、胺化制得。 适用于心脏性、肾脏性、肝脏性及其他水肿病,与降压药合用,可增加疗效。制剂为片剂。
用途
适用于心脏性、肾脏性、肝脏性及其他水肿病,与降压药合用,可增加疗效。制剂为片剂。