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N-[(7R)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]乙酰胺
N-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
化合物简介
The R-enantiomer of Colchicine. An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
基本信息
CAS:75520-89-7
中文别名:
英文别名:(+)-Colchicin;Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,(R);(R)-7-Acetylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on;Lopac-C-9754;Colchicine,(R)-Isomer;COLCHICINE,(+);
分子式:C22H25NO6
分子量:399.437
精确质量:399.168
Psa:83.09
Logp:3.2625
中文别名:
英文别名:(+)-Colchicin;Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,(R);(R)-7-Acetylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on;Lopac-C-9754;Colchicine,(R)-Isomer;COLCHICINE,(+);
分子式:C22H25NO6
分子量:399.437
精确质量:399.168
Psa:83.09
Logp:3.2625
编号系统
物化性质
密度:1.25g/cm3
沸点:726ºC at 760 mmHg
熔点:106-132ºC
闪点:392.9ºC
折射率:1.584
储存条件:-20ºC Freezer
沸点:726ºC at 760 mmHg
熔点:106-132ºC
闪点:392.9ºC
折射率:1.584
储存条件:-20ºC Freezer
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict

13C NMR : Predict
