Spirorenone (INN) (developmental code name ZK-35973) is a steroidal antimineralocorticoid of the spirolactone group that was never marketed. Spirorenone possesses 5–8 times the antimineralocorticoid activity of spironolactone in animal studies. The initial discovery of spirorenone was deemed a great success, as no compound with greater antimineralocorticoid activity had been developed since spironolactone in 1957. Moreover, spirorenone itself has virtually no affinity for the androgen receptor while its progestogenic activity shows species differences, being somewhat greater than that of spironolactone in rabbits but absent in mice and rats. As such, it was characterized as a highly potent antimineralocorticoid with far fewer hormonal side effects relative to spironolactone.

CAS：74220-07-8
中文别名：
英文别名：(6R,7R,8R,9S,10R,13S,14R,15S,16S,17S)-3\',4\',6,7,8,9,11,12,13,14,15,16,20,21-Tetradecahydro-10,13-dimethylspiro(17H-dicyclopropa(6,7:15,16)cyclopenta(A)phenanthrene-17,2\'(5\'H)-furan)-3(10H),5\'-dione;Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(A)phenanthrene-17,2\'(5\'H)-furan)-3,5\'(10H)-dione,3\',4\',6,7,8,9,11,12,13,14,15,16,20,21-tetradecahydro-10,13-dimethyl-,(6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta));Spirorenonum [inn-latin];Spirorenonum;Espirorenona;Espirorenona [inn-spanish];
分子式：C24H28O3
分子量：364.477
精确质量：364.204
Psa：43.37
Logp：4.0819

EINECS号：277-770-1

密度：1.28g/cm3
沸点：556.1ºC at 760 mmHg
闪点：243.7ºC
折射率：1.627