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化合物简介

Nortriptyline is a second-generation tricyclic antidepressant (TCA) marketed as the hydrochloride salt under the trade names Sensoval, Aventyl, Pamelor, Norpress, Allegron, Noritren and Nortrilen. It is used in the treatment of major depression and childhood nocturnal enuresis (bedwetting). Its off-label uses include treatment of chronic fatigue syndrome, chronic pain and migraine, and labile affect in some neurological disorders.

基本信息

CAS:72-69-5
中文别名
英文别名:allegron;Aventyl;Sesaval;notriptyline;Avantyl;desmethylamitriptyline;[14C]-Nortriptyline;NORTRIPTYLINE;Psychostyl;Ateben;noramitriptyline;lambeck;Noritren;Lumbeck;
分子式:C19H21N
分子量:263.377
精确质量:263.167
Psa:12.03
Logp:4.2173

编号系统

UNII:BL03SY4LXB

物化性质

密度:1.084 g/cm3
沸点:403.4ºC at 760 mmHg
闪点:194.9ºC
折射率:1.633

安全信息

海关编码:2921499090

生产方法及用途

合成路线

  • 参考文献

    WO2013/168008 A1, ; Paragraph 00104; 00105 ;

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


Mass spectrum (electron ionization)


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