化学科研者一站式服务平台

结构式搜索
当前位置：
  • 首页

  • 化合物简介

    Mestranol (INN, USAN, BAN, JAN) (brand names Devocin, Ovastol, Tranel), also known as ethinyl estradiol methyl ether (EEME), is a synthetic, steroidal estrogen that has been widely used medically. It was employed as the estrogen component in many of the first oral contraceptives, such as mestranol/noretynodrel (brand names Enovid, Enavid), and is still in use today. It was also a component of Ortho-Novin, Femigen, and Norbiogest. In addition to its use as an oral contraceptive, mestranol has been used as a component of hormone replacement therapy.

    基本信息

    CAS：72-33-3
    中文别名：(17α)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol;3-甲氧基-17α-乙炔雌二醇;炔雌醇甲醚;
    英文别名：SC 4725;Norquen;RS 1044;d-MVE;EE3ME;19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17 -)-;17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether;Mestranol;Devocin;Ovastol;
    分子式：C21H26O2
    分子量：310.43
    精确质量：310.193
    Psa：29.46
    Logp：3.9156

    编号系统

    UNII：B2V233XGE7

    物化性质

    外观与性状：结晶固体
    密度：0.905g/cm3
    沸点：464.1ºC at 760 mmHg
    熔点：153-155°C(lit.)
    闪点：224.1ºC
    折射率：1.49
    储存条件：-20ºC Freezer

    安全信息

    RTECS号：RC8960000
    安全说明：S22; S26; S36/37/39; S45; S36/37
    WGK Germany：3
    危险类别码：R36/37/38; R40; R48
    危险品标志：Xn
    危险性描述：H315; H319; H351
    危险标志：GHS07, GHS08
    信号词：Warning
    危险性防范说明：P281; P305 + P351 + P338

    生产方法及用途

    用途
    主要用于卵巢功能不全、闭经、功能性子宫出血、更年期综合征等。

    合成路线

    • 参考文献

      Wong, Fung Fuh; Chuang, Shih Hsien; Yang, Sheng-chuan; Lin, Yu-Hsiang; Tseng, Wen-Che; Lin, Shao-Kai; Huang, Jiann-Jyh Tetrahedron, 2010 , vol. 66, # 23 p. 4068 - 4072

    上游原料

    下游产品

    图谱

    Predict 1H proton NMR


    13C NMR : Predict


    1H NMR : Predict


    13C NMR : in CDCl3


    Mass spectrum (electron ionization)


    Mass


    IR : nujol mull


    IR : KBr disc


    加载中...