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(3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮
(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione
化合物简介
Plinabulin (NPI-2358) is a 2,5-diketopiperazine derivative that is being developed as an experimental cancer drug. It is a synthetic analog of the natural compound phenylahistin. Plinabulin interrupts tumor blood flow via disruption of the tumor's vascular endothelial cells resulting in tumor necrosis. It also has a tubulin-depolymerizing activity.
基本信息
CAS：714272-27-2
中文别名：普那布林;
英文别名：3-(Z)-benzylidene-6-(((Z)-5-tert-butyl-1H-imidazol-4-yl)methylene)-piperazine-2,5-dione;3-Z-benzylidene-6-(5\"-tert-butyl-1H-imidazol-4\"-Z-ylmethylene)-piperazine-2,5-dione;Plinabulin,NPI2358,NPI-2358;tert-butyl-dehydrophenylahistin;Plinabulin,NPI2358;NPI 2358;NPI-2358/KPU-2;Plinabulin;Plinabulin [USAN:INN];
分子式：C19H20N4O2
分子量：336.388
精确质量：336.159
Psa：94.92
Logp：1.566
中文别名：普那布林;
英文别名：3-(Z)-benzylidene-6-(((Z)-5-tert-butyl-1H-imidazol-4-yl)methylene)-piperazine-2,5-dione;3-Z-benzylidene-6-(5\"-tert-butyl-1H-imidazol-4\"-Z-ylmethylene)-piperazine-2,5-dione;Plinabulin,NPI2358,NPI-2358;tert-butyl-dehydrophenylahistin;Plinabulin,NPI2358;NPI 2358;NPI-2358/KPU-2;Plinabulin;Plinabulin [USAN:INN];
分子式：C19H20N4O2
分子量：336.388
精确质量：336.159
Psa：94.92
Logp：1.566
编号系统
MDL号：MFCD18074510
物化性质
密度：1.267
沸点：730.345ºC at 760 mmHg
闪点：395.498ºC
沸点：730.345ºC at 760 mmHg
闪点：395.498ºC
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict
