Digitoxin is a cardiac glycoside. It is similar in structure and effects to digoxin (though the effects are longer-lasting). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function. However, it is now rarely used in current Western medical practice. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.

CAS：71-63-6
中文别名：洋地黄毒甙;
英文别名：tridigitoxosyldigitoxigenin;Ditaven;digicor;[3H]-Digitoxin;Natigal;Acedoxin;Myodigin;DIGITOXIN;Digimed;Digitrin;Cardigin;Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-β-D, 14-dihydroxy-;Digilong;De-Tone;
分子式：C41H64O13
分子量：764.939
精确质量：764.435
Psa：182.83
Logp：3.2473

UNII：E90NZP2L9U

外观与性状：白色粉末
密度：1.33 g/cm3
沸点：902.3ºC at 760 mmHg
熔点：240ºC (dec.)(lit.)
闪点：269.5ºC
折射率：1.593
储存条件：库房低温,通风,干燥,与食品原料分开存放

RTECS号：IH2275000
安全说明：S45
WGK Germany：3
危险类别码：R23/25; R33
危险品运输编码：UN 2811
危险类别：6.1(a)
包装等级：II
危险品标志：T
危险标志：GHS06, GHS08
危险性描述：H301; H331; H373
信号词：Danger
危险性防范说明：P261; P301 + P310; P311

生产方法
1.通常以洋地黄叶为原料提取。工艺路线如下：洋地黄叶去杂干燥粉碎H2O28～35℃发酵过滤叶粉70%乙醇浸提过滤滤液浓缩去胶4～6h氯仿提取分离氯仿提取液水洗5%NaOH洗涤水洗浓缩黏稠物丙酮热溶冷却静置0～5℃过滤粗品柱色谱纯化产品 能加强心肌收缩力、减慢心率和抑制传导。适用于慢性心功能不全患者长期服用。
用途
能加强心肌收缩力、减慢心率和抑制传导。适用于慢性心功能不全患者长期服用。