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化合物简介
3-Hydroxyphenazepam is a benzodiazepine with hypnotic, sedative, anxiolytic, and anticonvulsant properties. It is an active metabolite of phenazepam, as well as the active metabolite of the benzodiazepine prodrug cinazepam. Relative to phenazepam, 3-hydroxyphenazepam has diminished myorelaxant properties, but is about equivalent in most other regards. Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an EC50 value of 10.3 nM. It has been sold online as a designer drug.
基本信息
CAS：70030-11-4
中文别名：
英文别名：3-Hydroxyfenazepam;3-hydroxyphenazepam;7-bromo-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one;7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one;3-Oxyfenazepam;7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2h-1,4-benzodiazepin-2-one;
分子式：C15H10BrClN2O2
分子量：365.609
精确质量：363.961
Psa：65.18
Logp：2.7311
中文别名：
英文别名：3-Hydroxyfenazepam;3-hydroxyphenazepam;7-bromo-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one;7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one;3-Oxyfenazepam;7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2h-1,4-benzodiazepin-2-one;
分子式：C15H10BrClN2O2
分子量：365.609
精确质量：363.961
Psa：65.18
Logp：2.7311
编号系统
UNII：1KJ8MP77JK
物化性质
密度：1.7g/cm3
沸点：544.5ºC at 760 mmHg
闪点：283.1ºC
折射率：1.712
沸点：544.5ºC at 760 mmHg
闪点：283.1ºC
折射率：1.712
安全信息
生产方法及用途
合成路线
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参考文献
Davidenko, T. I.; Zabolotskaya, N. N.; Milienko, N. P.; Andronati, S. A.; Kuznetsov, V. D.; Bogatskii, A. V. Doklady Chemistry, 1984 , vol. 278, p. 335 - 337 Dokl. Akad. Nauk SSSR Ser. Khim., 1984 , vol. 278, # 4 p. 878 - 881
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
