Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue that was investigated as a potential therapy for hepatitis B virus infection. In a 1993 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from liver failure associated with lactic acidosis; two further participants required liver transplantation. This toxicity was unusual in that it was not predicted by animal studies. It is suspected that the drug's toxicity was due to its damaging mitochondria.

CAS：69123-98-4
中文别名：5-碘-2\'-氟脱氧尿苷;1-[(2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)氧杂环戊-2-基]-5-碘嘧啶-2,4-二酮;1-(2-脱氧-2-氟-β-D-阿拉伯呋喃基)-5-碘尿嘧啶;
英文别名：1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione;
分子式：C9H10FIN2O5
分子量：372.089
精确质量：371.962
Psa：104.55
Logp：-1.2701

MDL号：MFCD00866922

外观与性状：无色晶体
密度：2.18 g/cm3
熔点：216-217ºC
折射率：1.685

海关编码：2934999090