Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor (DRI). GBR-12909 binds to the target site on the dopamine transporter (DAT) ~ 50 times more strongly than cocaine, but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels, giving vanoxerine only mild stimulant effects. Vanoxerine has also been observed to be a potent blocker of the IKr (hERG) channel. It is possible to see that the structure is based on Flunamine.

CAS：67469-78-7
中文别名：1-(2-[双(4-氟苯基)甲氧基]乙基)-4-(3-苯基丙基)哌嗪二盐酸盐;伐洛司林二盐酸盐;
英文别名：1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine,dihydrochloride;Vanoxerine hydrochloride;Vanoxerine dihydrochloride;I 893;1-[2-[bis(4-fluorophenyl)methoxy]-ethyl]-4-[3-phenylpropyl]piperazine dihydrochloride;
分子式：C28H34Cl2F2N2O
分子量：523.485
精确质量：522.202
Psa：15.71
Logp：6.801

MDL号：MFCD00055193

外观与性状：白色固体
沸点：542.7ºC at 760 mmHg
闪点：282ºC