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化合物简介
Gliotoxin is a sulfur-containing mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines produced by several species of fungi, especially those of marine origin. It is the most prominent member of the epipolythiopiperazines, a large class of natural products featuring a diketopiperazine with di- or polysulfide linkage. These highly bioactive compounds have been the subject of numerous studies aimed at new therapeutics. Gliotoxin was originally isolated from Gliocladium fimbriatum, and was named accordingly. It is an epipolythiodioxopiperazine metabolite.
基本信息
CAS:67-99-2
中文别名:胶黏毒素;
英文别名:Gliotoxin,(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione;
分子式:C13H14N2O4S2
分子量:326.391
精确质量:326.039
Psa:131.68
Logp:-0.4279
中文别名:胶黏毒素;
英文别名:Gliotoxin,(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione;
分子式:C13H14N2O4S2
分子量:326.391
精确质量:326.039
Psa:131.68
Logp:-0.4279
编号系统
UNII:5L648PH06K
物化性质
密度:1.74g/cm3
沸点:699.7ºC at 760 mmHg
熔点:153.5ºC
闪点:377ºC
折射率:1.813
储存条件:库房通风低温干燥,与食品原料分开储运
沸点:699.7ºC at 760 mmHg
熔点:153.5ºC
闪点:377ºC
折射率:1.813
储存条件:库房通风低温干燥,与食品原料分开储运
安全信息
RTECS号:KB4725000
危险类别码:R25
WGK Germany:3
危险品运输编码:UN 3462 6.1/PG 3
危险类别:6.1(b)
包装等级:III
危险类别码:R25
WGK Germany:3
危险品运输编码:UN 3462 6.1/PG 3
危险类别:6.1(b)
包装等级:III
生产方法及用途
用途
具有免疫调节活性,抗菌谱较广,能抑制霉菌、细菌和病毒,也可用作农药。
具有免疫调节活性,抗菌谱较广,能抑制霉菌、细菌和病毒,也可用作农药。
合成路线
上游原料
下游产品
图谱
Predict 1H proton NMR

13C NMR : Predict

1H NMR : Predict
