Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

CAS：67-73-2
中文别名：乙酸肤轻松;醋酸肤轻松;肤轻松;氟轻松;仙乃乐;6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione;11b-羟基-16a,17-[(1-甲基亚乙基)-双(氧)]-21-(乙酰氧基)-6a,9-二氟孕甾-1,4-二烯-3,20-二酮;
英文别名：Fluocinolone acetonide;Fluocinolone Acetonide;
分子式：C24H30F2O6
分子量：452.488
精确质量：452.201
Psa：93.06
Logp：2.3668

UNII：0CD5FD6S2M

密度：1.36g/cm3
沸点：579ºC
熔点：267-269°C(lit.)
折射率：103 ° (C=1, MeOH)
储存条件：Keep tightly closed. Store in a cool dry place.

RTECS号：TU3830000
安全说明：S26-S36-S22
WGK Germany：3
危险类别码：R20/21/22; R36/37/38; R40
海关编码：2937210000
危险品标志：Xn

用途
为外用皮质激素，涂于皮肤患处，治疗皮肤过敏而引起瘙痒，粘膜的炎症，神经性皮炎、接触皮炎、日光性皮炎、牛皮癣等，特别适合用于婴儿湿疹，且疗效显著，副作用少，奏效快，止痒效果好。