2-Bromo-4-methylphenol is a useful synthetic intermediate. It was used in the synthesis of furan-2-ylmethylene thiazolidinediones as potent, and selective inhibitors of phosphoinositide 3-kinase γ. It was also a reactant used to prepare phosphoramidate and phosphorothioamidate analogs of amiprophos Me as potential antimalarial agents.

CAS：6627-55-0
中文别名：4-甲基-2-溴苯酚;2-溴对甲酚;邻溴对甲酚;2-溴对甲基苯酚;2-溴-4-甲基酚;
英文别名：2-Bromo-p-cresol;2-bromo para-cresol;EINECS 229-595-7;Phenol, 2-bromo-4-methyl-;p-CRESOL,2-BROMO;Phenol,2-bromo-4-methyl;2-bromo-4-methyl phenol;3-Bromo-4-hydroxytoluene;4-methyl-2-bromophenol;
分子式：C7H7BrO
分子量：187.034
精确质量：185.968
Psa：20.23
Logp：2.4631

MDL号：MFCD00002151
EINECS号：229-595-7

外观与性状：透明无色至淡黄色液体
密度：1.547g/mLat 25°C(lit.)
沸点：213-214°C(lit.)
熔点：213-214 °C
闪点：>230°F
折射率：n20/D 1.578(lit.)
稳定性：Stable at room temperature in closed containers under normal storage and handling conditions.
储存条件：Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

RTECS号：GO6868200
安全说明：S26-S37/39-S36/37/39-S24/25
危险类别码：R21/22; R36/37/38
WGK Germany：3
海关编码：2908199090
危险品标志：Xn

生产方法
由2-溴-4-甲基苯胺重氮化、水解而得:将稀硫酸加到2-溴-4-甲基苯中,搅拌冷却,在5℃以下加入亚硝酸钠水溶液,温度保持在5℃以下,然后再加冷水、尿素和碎冰,得重氮盐溶液。再将无水硫酸钠、浓硫酸和水加热,在130~135℃分批加入重氮盐溶液,然后分批加入水进行蒸馏,所得馏出液用乙醚提取,用10%碳酸氢钠溶液洗涤,再经无水硫酸钠干燥,过滤,滤液蒸去乙醚而得成品。另一种方法是由对甲苯酚在氯仿溶剂中直接溴化 有机合成中间体
用途
有机合成中间体